:root{--cream: #F5F2EF;--charcoal: #1A1A1A;--rose: #C4788A;--card: #ffffff;--shadow: 0 1px 4px rgba(0, 0, 0, .08);--shadow-lg: 0 6px 24px rgba(0, 0, 0, .1);--radius: 8px;--radius-sm: 6px;--text: #1A1A1A;--muted: #888;--muted-2: #666;--line: #ececec;--bg-soft: #faf8f6;--teal: #17A398;--teal-dark: #0F7D74;--green: #2E9E6B;--violet: #7A6FB0;--amber: #D9812B;--red: #C0453A;--band: rgba(23, 163, 152, .12)}*{box-sizing:border-box}html,body,#root{height:100%}body{margin:0;background:var(--cream);color:var(--text);font-family:DM Sans,system-ui,-apple-system,sans-serif;-webkit-font-smoothing:antialiased}a{color:inherit}h1,h2,h3,h4,p{margin:0}button{font-family:inherit}.shell{min-height:100%;display:flex;flex-direction:column}.topbar{display:flex;align-items:center;gap:2rem;background:var(--charcoal);color:var(--cream);padding:0 1.75rem;height:60px;position:sticky;top:0;z-index:10}.brand{display:flex;align-items:center;white-space:nowrap}.brand-chip{background:#fff;border-radius:8px;padding:.3rem .7rem;display:flex;align-items:center}.brand-chip img{height:26px;width:auto;display:block}.brand-fallback-text{display:none;color:var(--charcoal);font-size:1rem;font-weight:700}.brand-fallback-text b{color:var(--rose)}.brand-chip-fallback .brand-fallback-text{display:inline}.topnav{display:flex;gap:.35rem;flex:1}.navlink{color:#f5f2efa8;text-decoration:none;font-size:.82rem;font-weight:500;padding:.4rem .7rem;border-radius:999px;white-space:nowrap;transition:color .12s,background .12s}.navlink:hover{color:var(--cream);background:#ffffff0f}.navlink.active{color:var(--charcoal);background:var(--teal)}.investor{font-size:.78rem;color:#f5f2ef99;white-space:nowrap}.investor strong{color:var(--cream);font-weight:600}.content{flex:1;width:100%;max-width:1200px;margin:0 auto;padding:2rem 1.75rem 3rem}.footer{text-align:center;font-size:.72rem;color:var(--muted);padding:1rem;border-top:1px solid var(--line)}@media (max-width: 820px){.topbar{flex-wrap:wrap;height:auto;padding:.6rem 1rem;gap:.75rem}.topnav{order:3;flex-basis:100%;overflow-x:auto}.investor{order:2}}.gate{min-height:100vh;display:flex;align-items:center;justify-content:center;background:var(--cream);padding:2rem}.gate-card{background:#fff;border-radius:12px;box-shadow:var(--shadow-lg);padding:2.25rem 2rem;width:100%;max-width:380px;text-align:center}.gate-brand{min-height:40px;margin-bottom:1.25rem;display:flex;justify-content:center}.gate-brand img{max-height:44px;max-width:240px}.gate-lead{font-size:.95rem;color:var(--muted-2);margin-bottom:1.25rem}.gate-input{width:100%;font-size:1rem;padding:.7rem .9rem;border:1px solid var(--line);border-radius:var(--radius);font-family:inherit;text-align:center}.gate-input:focus{outline:2px solid var(--teal);border-color:var(--teal)}.gate-error{color:var(--red);font-size:.82rem;margin-top:.5rem}.gate-btn{width:100%;margin-top:1rem;background:var(--charcoal);color:var(--cream);border:none;border-radius:var(--radius);padding:.7rem;font-size:.95rem;font-weight:600;cursor:pointer}.gate-btn:hover{opacity:.9}.gate-foot{font-size:.68rem;color:var(--muted);margin-top:1.5rem}.evidence-strip{background:#14201f;border:1px solid var(--teal-dark);border-radius:var(--radius);padding:1rem 1.2rem;margin-bottom:1.25rem}.evidence-strip-label{font-size:.7rem;font-weight:700;text-transform:uppercase;letter-spacing:.06em;color:var(--teal);margin-bottom:.6rem}.evidence-strip-list{list-style:none;margin:0;padding:0}.evidence-strip-list li{padding:.4rem 0;border-top:1px solid rgba(255,255,255,.08);display:flex;justify-content:space-between;gap:1rem;flex-wrap:wrap}.evidence-strip-list li:first-child{border-top:none}.evidence-text{color:#eaf2f0;font-size:.86rem;line-height:1.45;flex:1;min-width:220px}.evidence-src{color:#8fb8b2;font-size:.74rem;font-style:italic;white-space:nowrap}.evidence-quote{position:relative;margin:0 0 1.5rem;padding:1rem 1.25rem 1rem 2.4rem;background:var(--band);border-left:3px solid var(--teal);border-radius:var(--radius);font-size:1.05rem;line-height:1.5;color:var(--charcoal);font-style:italic}.evidence-quote-mark{position:absolute;left:.7rem;top:.3rem;font-size:2rem;color:var(--teal);font-family:Georgia,serif}.evidence-quote cite{display:block;margin-top:.5rem;font-size:.8rem;font-style:normal;color:var(--muted-2)}.hero{margin-bottom:1.5rem}.hero-kicker{font-size:.95rem;font-weight:600;color:var(--teal-dark);letter-spacing:.02em;margin-bottom:.5rem}.hero-title{font-size:2rem;font-weight:700;line-height:1.18;max-width:900px}.mup-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(240px,1fr));gap:1rem;margin-bottom:1.75rem}.mup-card{background:var(--card);border-radius:var(--radius);box-shadow:var(--shadow);padding:1.1rem 1.2rem;border-top:3px solid var(--teal)}.mup-step{display:flex;align-items:center;gap:.55rem;margin-bottom:.5rem}.mup-num{width:1.7rem;height:1.7rem;border-radius:50%;background:var(--charcoal);color:var(--cream);display:flex;align-items:center;justify-content:center;font-size:.85rem;font-weight:700}.mup-key{font-size:1.15rem;font-weight:700}.mup-desc{font-size:.85rem;color:var(--muted-2);line-height:1.5}.chain{display:flex;align-items:center;flex-wrap:wrap;gap:.3rem;background:var(--charcoal);border-radius:var(--radius);padding:.9rem 1.1rem;margin-bottom:.6rem}.chain-wrap{display:inline-flex;align-items:center;gap:.3rem}.chain-node{color:var(--cream);font-size:.82rem;font-weight:600;padding:.3rem .6rem;border:1px solid rgba(245,242,239,.25);border-radius:999px;white-space:nowrap}.chain-node-key{background:var(--teal);color:var(--charcoal);border-color:var(--teal)}.chain-arrow{color:var(--teal);font-weight:700}.chain-caption{font-size:.85rem;color:var(--muted-2);margin-bottom:2rem;line-height:1.45}.traction-grid{display:grid;grid-template-columns:1fr 1fr;gap:1rem;margin-bottom:.6rem}.traction-card{background:var(--card);border-radius:var(--radius);box-shadow:var(--shadow);padding:1rem 1.2rem;border-left:3px solid var(--rose)}.traction-card-wide{grid-column:1 / -1}.traction-card h4{font-size:.8rem;text-transform:uppercase;letter-spacing:.04em;color:var(--muted-2);margin-bottom:.5rem}.traction-card ul{margin:0;padding-left:1.1rem}.traction-card li{font-size:.9rem;margin-bottom:.25rem;line-height:1.4}.section-h{font-size:1.15rem;font-weight:700;margin:1.5rem 0 1rem}.indication-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(220px,1fr));gap:1rem;margin-bottom:1rem}.ind-tile{background:var(--card);border-radius:var(--radius);box-shadow:var(--shadow);padding:1rem 1.1rem;display:flex;flex-direction:column;gap:.35rem;border:1px solid transparent}.ind-live{border-color:var(--teal)}.ind-badge{align-self:flex-start;font-size:.65rem;font-weight:700;text-transform:uppercase;letter-spacing:.05em;padding:.15rem .5rem;border-radius:999px;background:var(--teal);color:#fff}.ind-badge-soon{background:#e8e4df;color:var(--muted-2)}.ind-name{font-size:1.05rem;font-weight:700}.ind-note{font-size:.8rem;color:var(--muted-2);line-height:1.4}.ind-note-dim{color:var(--muted);font-size:.74rem}.principle{background:var(--band);border-left:3px solid var(--teal);border-radius:var(--radius);padding:1rem 1.25rem;font-size:1rem;font-weight:600;line-height:1.5;color:var(--charcoal);margin:1.5rem 0}.whopays{display:grid;grid-template-columns:repeat(auto-fit,minmax(200px,1fr));gap:1rem}.whopays-item{background:var(--bg-soft);border-radius:var(--radius);padding:.9rem 1rem;border-left:3px solid var(--rose)}.whopays-item h4{font-size:.9rem;font-weight:700;margin-bottom:.3rem}.whopays-item p{font-size:.8rem;color:var(--muted-2);line-height:1.45}.synthetic-note{font-size:.82rem;color:var(--muted-2);margin-top:2rem;line-height:1.5}.synthetic-note a{color:var(--teal-dark);font-weight:600}@media (max-width: 720px){.traction-grid{grid-template-columns:1fr}.hero-title{font-size:1.6rem}}.page-header{display:flex;align-items:flex-start;justify-content:space-between;gap:1rem;flex-wrap:wrap;margin-bottom:1.5rem}.page-title{font-size:1.5rem;font-weight:700;line-height:1.2}.page-customer{font-size:.9rem;color:var(--muted-2);margin-top:.35rem}.card{background:var(--card);border-radius:var(--radius);box-shadow:var(--shadow);padding:1.25rem;margin-bottom:1.25rem}.card-head{display:flex;align-items:baseline;justify-content:space-between;gap:.75rem;margin-bottom:1rem}.card-title{font-size:.95rem;font-weight:700}.card-subtitle{font-size:.78rem;color:var(--muted)}.kpi-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(150px,1fr));gap:1rem;margin-bottom:1.25rem}.kpi{background:var(--card);border-radius:var(--radius);box-shadow:var(--shadow);padding:1rem 1.1rem;border-left:3px solid var(--teal)}.kpi-label{font-size:.72rem;text-transform:uppercase;letter-spacing:.04em;color:var(--muted-2);display:flex;align-items:center;gap:.4rem}.kpi-illus{text-transform:none;letter-spacing:0;font-size:.6rem;color:var(--amber);border:1px solid var(--amber);border-radius:4px;padding:0 .25rem}.kpi-value{font-size:1.7rem;font-weight:700;margin-top:.3rem;line-height:1.1}.kpi-sub{font-size:.75rem;color:var(--muted);margin-top:.2rem}.filter-bar{display:flex;flex-wrap:wrap;gap:.9rem;background:var(--card);border-radius:var(--radius);box-shadow:var(--shadow);padding:1rem 1.1rem;margin-bottom:1.25rem}.field{display:flex;flex-direction:column;gap:.3rem}.field-label{font-size:.7rem;text-transform:uppercase;letter-spacing:.04em;color:var(--muted-2)}.field-select{font-size:.85rem;padding:.4rem .6rem;border:1px solid var(--line);border-radius:var(--radius-sm);background:#fff;color:var(--text);min-width:130px;cursor:pointer}.callout{border-radius:var(--radius);padding:.9rem 1.1rem;font-size:.9rem;line-height:1.5}.callout-teal{background:var(--band);border-left:3px solid var(--teal)}.callout-rose{background:#c4788a1f;border-left:3px solid var(--rose)}.caption{font-size:.82rem;color:var(--muted-2);margin-top:.75rem;line-height:1.45}.charts-2col{display:grid;grid-template-columns:repeat(auto-fit,minmax(340px,1fr));gap:1.25rem}.patient-pick{margin-left:auto;display:flex;align-items:center;gap:.5rem;font-size:.78rem;color:var(--muted-2)}.patient-pick select{font-size:.82rem;padding:.4rem .6rem;border:1px solid var(--line);border-radius:var(--radius-sm);background:#fff;cursor:pointer}.copilot-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(300px,1fr));gap:1.25rem;align-items:start}.cov-list{margin:0 0 1rem}.cov-list>div{display:flex;justify-content:space-between;padding:.35rem 0;border-bottom:1px solid var(--line);font-size:.85rem}.cov-list dt{color:var(--muted-2)}.cov-list dd{margin:0;font-weight:600;text-transform:capitalize}.gauge-title{font-size:.72rem;text-transform:uppercase;letter-spacing:.04em;color:var(--muted-2);margin:.5rem 0 1.4rem}.gauge{margin-bottom:.5rem}.gauge-track{position:relative;height:10px;background:#eef0ef;border-radius:999px;margin:1.6rem 0 .4rem}.gauge-band{position:absolute;top:0;height:100%;background:var(--band);border-left:2px solid var(--teal);border-right:2px solid var(--teal);border-radius:2px}.gauge-marker{position:absolute;top:-1.35rem;transform:translate(-50%);display:flex;flex-direction:column;align-items:center;font-size:.65rem;white-space:nowrap}.gauge-dot{width:10px;height:10px;border-radius:50%;margin-top:2px;box-shadow:0 0 0 3px #fff;order:2;position:relative;top:.7rem}.gauge-mlabel{order:1;font-weight:600}.gauge-scale{display:flex;justify-content:space-between;font-size:.68rem;color:var(--muted)}.gauge-target{color:var(--teal);font-weight:600}.labs-strip{display:grid;grid-template-columns:repeat(5,1fr);gap:.4rem;margin-bottom:.5rem}.labs-strip>div{background:var(--bg-soft);border-radius:var(--radius-sm);padding:.4rem .2rem;text-align:center}.labs-strip span{display:block;font-size:.6rem;color:var(--muted-2);text-transform:uppercase;letter-spacing:.02em}.labs-strip b{display:block;font-size:.95rem;font-weight:700}.labs-strip i{font-size:.55rem;color:var(--muted);font-style:normal}.response-block{margin-top:1rem;padding-top:.85rem;border-top:1px solid var(--line)}.response-head{display:flex;align-items:center;justify-content:space-between;gap:.5rem;margin-bottom:.4rem}.resp-badge{font-size:.68rem;font-weight:700;padding:.15rem .55rem;border-radius:999px;white-space:nowrap}.resp-responding{background:#e6f4ef;color:#1c7a56}.resp-partial-response{background:#fbf0e2;color:#9a5a12}.resp-not-responding{background:#fce8e8;color:#b00020}.care-gap{margin-top:.5rem;font-size:.78rem;line-height:1.45;color:#9a5a12;background:#fbf4ee;border-left:3px solid var(--amber);padding:.5rem .7rem;border-radius:var(--radius-sm)}.sparkline{width:100%;height:44px;display:block}.sparkline polyline{fill:none;stroke:var(--teal);stroke-width:2;vector-effect:non-scaling-stroke}.response-line{font-size:.8rem;color:var(--muted-2);margin-top:.35rem;line-height:1.4}.resp-down{color:#1c7a56}.resp-up{color:#b00020}.status-chip{display:inline-block;margin-top:.6rem;font-size:.75rem;font-weight:600;padding:.25rem .6rem;border-radius:999px}.status-in_range{background:#e6f4ef;color:#1c7a56}.status-below{background:#fdeee8;color:#b55a1a}.status-above{background:#fce8e8;color:#b00020}.dose-flow{display:flex;align-items:center;gap:.75rem;margin-bottom:.75rem}.dose-box{flex:1;border:1px solid var(--line);border-radius:var(--radius);padding:.6rem;text-align:center}.dose-box-new{border-color:var(--teal);background:var(--band)}.dose-cap{display:block;font-size:.65rem;text-transform:uppercase;letter-spacing:.04em;color:var(--muted-2)}.dose-val{display:block;font-size:1.6rem;font-weight:700;line-height:1.1}.dose-unit{font-size:.7rem;color:var(--muted)}.dose-arrow{color:var(--muted);font-size:1.2rem}.rec-sentence{font-size:.9rem;line-height:1.5;margin-bottom:.4rem}.rec-calc{font-family:ui-monospace,SF Mono,Menlo,monospace;font-size:.76rem;color:var(--teal-dark);background:var(--band);padding:.5rem .65rem;border-radius:var(--radius-sm);margin-bottom:.5rem}.rec-uncertainty{font-size:.75rem;color:var(--muted);margin-top:.5rem}.similar-block{margin-top:.85rem;padding:.75rem .85rem;background:var(--band);border-radius:var(--radius-sm);border-left:3px solid var(--teal)}.similar-count{font-size:.9rem}.similar-count b{font-size:1.15rem;color:var(--teal-dark)}.similar-crit{font-size:.76rem;color:var(--muted-2);margin-top:.2rem}.similar-spread{font-size:.78rem;color:var(--text);margin-top:.4rem;line-height:1.45}.hist-wrap{overflow-x:auto}.hist-table{width:100%;border-collapse:collapse;font-size:.82rem}.hist-table th{text-align:left;padding:.5rem .6rem;font-size:.68rem;text-transform:uppercase;letter-spacing:.03em;color:var(--muted-2);border-bottom:2px solid var(--line);white-space:nowrap}.hist-table td{padding:.5rem .6rem;border-bottom:1px solid var(--line);white-space:nowrap}.hist-table tr:last-child td{border-bottom:none}.status-pill{display:inline-block;font-size:.68rem;font-weight:600;padding:.1rem .5rem;border-radius:999px}.status-pill.status-in_range{background:#e6f4ef;color:#1c7a56}.status-pill.status-below{background:#fdeee8;color:#b55a1a}.status-pill.status-above{background:#fce8e8;color:#b00020}.evidence-row{display:grid;grid-template-columns:repeat(auto-fit,minmax(220px,1fr));gap:.9rem;margin:1.25rem 0}.evidence-chip{background:#fff;border-radius:var(--radius);box-shadow:var(--shadow);padding:.8rem .9rem;border-top:3px solid var(--teal)}.evidence-chip p{font-size:.82rem;line-height:1.45}.evidence-src{font-size:.7rem;color:var(--muted);font-style:italic;margin-top:.4rem;display:block}.mdr-note{background:#fbf4ee;border:1px dashed var(--amber);border-radius:var(--radius);padding:.9rem 1.1rem;font-size:.82rem;line-height:1.5;color:var(--muted-2)}.mdr-note strong{color:var(--text)}.area-toggle{display:flex;align-items:center;gap:.5rem;flex-wrap:wrap;margin-bottom:1.25rem}.area-btn{border:1px solid var(--line);background:#fff;color:var(--muted-2);border-radius:999px;padding:.45rem 1rem;font-size:.85rem;font-weight:600;cursor:pointer}.area-btn.active{background:var(--charcoal);color:var(--cream);border-color:var(--charcoal)}.sim-controls{align-items:flex-end}.slider-field{min-width:190px}.slider-field input[type=range]{width:100%;accent-color:var(--teal);cursor:pointer;margin-top:.35rem}.slider-field .field-label b{color:var(--teal-dark)}.snap-btn{align-self:flex-end;background:var(--teal);color:#fff;border:none;border-radius:var(--radius-sm);padding:.5rem .9rem;font-size:.85rem;font-weight:600;cursor:pointer;white-space:nowrap}.snap-btn:hover{background:var(--teal-dark)}.charts-3col{display:grid;grid-template-columns:repeat(auto-fit,minmax(280px,1fr));gap:1.25rem}.trial-cols{display:grid;grid-template-columns:1fr 1fr;gap:1.25rem;margin-bottom:1.25rem}.trial-col{background:var(--card);border-radius:var(--radius);box-shadow:var(--shadow);padding:1rem 1.2rem}.trial-h{font-size:.95rem;font-weight:700;margin-bottom:.75rem}.mini-kpis{display:flex;gap:1.5rem;flex-wrap:wrap}.mini-kpis>div{display:flex;flex-direction:column}.mini-kpis span{font-size:.7rem;text-transform:uppercase;letter-spacing:.03em;color:var(--muted-2)}.mini-kpis b{font-size:1.5rem;font-weight:700}.mini-kpis b.tox{color:var(--red)}.roadmap-tag{display:inline-block;font-size:.7rem;font-weight:700;text-transform:uppercase;letter-spacing:.05em;color:var(--amber);border:1px solid var(--amber);border-radius:999px;padding:.2rem .7rem;margin-bottom:1rem}.ask-box{display:flex;gap:.6rem;margin-bottom:.75rem}.ask-input{flex:1;font-size:.95rem;padding:.7rem .9rem;border:1px solid var(--line);border-radius:var(--radius);font-family:inherit}.ask-input:focus{outline:2px solid var(--teal);border-color:var(--teal)}.ask-btn{background:var(--charcoal);color:var(--cream);border:none;border-radius:var(--radius);padding:0 1.4rem;font-size:.9rem;font-weight:600;cursor:pointer}.ask-chips{display:flex;flex-wrap:wrap;gap:.5rem;margin-bottom:1.25rem}.ask-chip{background:var(--band);border:1px solid transparent;color:var(--teal-dark);border-radius:999px;padding:.4rem .8rem;font-size:.8rem;cursor:pointer}.ask-chip:hover{border-color:var(--teal)}.ask-insight{font-size:.95rem;line-height:1.55;margin-bottom:1rem}